Meanwhile, the results of cell cycle analysis and apoptosis analysis revealed that the knockdown of FBP1 could reverse the cell cycle arrest and apoptosis caused by GBE1 knockdown, indicating that FBP1 knockdown significantly promoted tumor proliferation, demonstrating the powerful tumor suppressive effect of FBP1 (Figure 6D–G, Supplementary Figure S1D–G). The gene discussed is GBE1; the disease is neoplasm.