Meanwhile, the results of cell cycle analysis and apoptosis analysis revealed that the knockdown of FBP1 could reverse the cell cycle arrest and apoptosis caused by GBE1 knockdown, indicating that FBP1 knockdown significantly promoted tumor proliferation, demonstrating the powerful tumor suppressive effect of FBP1 (Figure 6D–G, Supplementary Figure S1D–G). This evidence concerns the gene FBP1 and neoplasm.