HA-1-specific CD8+ T-lymphocytes exhibited marked cytotoxicity against PBMC from leukemia patients with HA-1+/+ and HA-1+/− genotypes, while no cytotoxic effect was observed against cells without HA-1 or HLA-A*02:01 expression (Figure 4C,D). This evidence concerns the gene ARHGAP45 and leukemia.