Longitudinal immunoPET imaging with [89Zr]Zr-DFO-CR011 in gpNMB-positive MDA-MB-468 xenograft models indicated that gpNMB was upregulated at 14 days post treatment initiation with dasatinib alone or with dasatinib and CDX-011 combination through the increase in tumor uptake of the tracer relative to baseline scans (Figure 5A–C). This evidence concerns the gene GPNMB and neoplasm.