Six out of nineteen CLL had a higher CNR1 expression than normal B cells from buffy coat (median of 0.4 relative fold increase; range 0.06–8.5), while all MCL samples expressed CNR1 at higher levels than normal B cells (median of 5.6 relative fold increase; range 3.3–27.6), which was significantly higher than in CLL cells (p = 0.0007). Here, CNR1 is linked to B-cell chronic lymphocytic leukemia.