CRP and metastatic neoplasm: A multivariate Cox regression model of these three negative prognostic factors at univariate analysis was performed (Table 5): pathological CRP (≥1.0 mg/dL) [HR of 3.67; 95% CI, 1.46 to 10.42] and metastatic disease [HR of 4.27; 95% CI, 1.58 to 11.47] were associated with a higher risk of death at 5 years (p < 0.05).