The increase of the majority of circulating adipokines like adiponectin, leptin, resistin, visfatin, osteopontin, apelin, and lipocalin has been linked with breast cancer, while on the contrary reduced circulating levels of the adipokines adiponectin and iridine (also known as adipo-mycin) has been shown to bear a protective role against it. This evidence concerns the gene SPP1 and breast carcinoma.