ER positive cases had significantly higher leptin levels than ER negative cases, Leptin and TNF-α levels were also significantly higher in lymph node metastasis (LNM) positive cases than in LNM negative cases, Leptin levels were significantly higher among post-menopausal cases than pre-menopausal cases. The gene discussed is LEP; the disease is metastatic malignant neoplasm in the lymph nodes.