The increase of the majority of circulating adipokines like adiponectin, leptin, resistin, visfatin, osteopontin, apelin, and lipocalin has been linked with breast cancer, while on the contrary reduced circulating levels of the adipokines adiponectin and iridine (also known as adipo-mycin) has been shown to bear a protective role against it. The gene discussed is SPP1; the disease is breast cancer.