Interestingly, exomiR-1229 was found to be upregulated in breast cancer and to trigger tumorigenesis by activating the Wnt/β-catenin pathway following targeting the key negative regulators of β-catenin such as glycogen synthase kinase (GSK)-3β, adenomatous polyposis coli (APC), and ICAT [48]. Here, APC is linked to breast carcinoma.