The above reported findings suggest that the lower expression of HIPK2 in cancer tissues, compared to the normal ones, could serve as a novel biomarker of HCC progression due to the HIF-1-induced angiogenesis, although the mechanisms leading to HIPK2 downregulation (e.g., hypoxia or microRNAs) in HCC have not been elucidated and might deserve further studies. This evidence concerns the gene HIF1A and cancer.