VEGFA and cancer: Following activation, HIF-1α translocates into the nucleus to bind HIF-1β and induce the transcription of several target genes involved in many aspects of cancer progression including angiogenesis (e.g., VEGF, PDGFB), metabolic adaptation (e.g., GLUT1, PDK1), apoptosis resistance (e.g., Bcl-2, MDR), invasion, and metastasis (e.g., CXCR4, MMP9) [15,16].