Hence, it is tempting to speculate that high levels of exomiR-1229 might induce tumor angiogenesis not only by blocking the HIPK2-mediated suppression of VEGF expression [45] but also by blocking the HIPK2-mediated inhibition of the β-catenin/VEGF pathway, although this latter hypothesis needs to be supported by further studies. This evidence concerns the gene HIPK2 and neoplasm.