The analysis of RNA-seq data from TCGA databases showed significant upregulation of genes encoding mesenchymal markers and EMT regulators such as CDH2 (coding N-cadherin), VIM (coding Vimentin), SNAIs and TWISTs in tumor samples, particularly in high-grade human gliomas (grade 4) and MES-GBMs (Supplementary Figure S4A,B). The gene discussed is VIM; the disease is central nervous system cancer.