NFKB1 and cancer: Mounting evidence has indicated that EF-24 has impeded cancer progression by employing multiple and interrelated mechanisms, such as the inhibition of NF-κB [31] and MAPK [32,33] signaling, the suppression of hypoxia-inducible factor-1α (HIF-1α) expression [34], glucose metabolism [35], and the regulation of reactive oxygen species (ROS) production [36,37].