In addition to the mutated genes that characterized each tumor, most MPMs also harbor loss-of-function mutations or the genetic loss of a few tumor suppressor genes (CDKN2A/2B, BAP1, NF2, TP53, LATS2 and SETD2), which likely plays a key role in neoplastic transformation [18,19]. Here, CDKN2A is linked to neoplasm.