Of all primary tumor types, Oral Squamous Cell Carcinoma (OSCC) and Pancreatic Adenocarcinoma (PAAD) express the highest levels of F3, PLAU, and SERPINE1 mRNA (encoding the uPA inhibitor PAI-1, Plasminogen Activator Inhibitor-1) [6,7]. The gene discussed is SERPINE1; the disease is pancreatic adenocarcinoma.