BRCA1 and neoplasm: A comprehensive study of 30 OC patients revealed that 7 (23%) had BRCA alterations (6 inherited and 1 acquired) detectable by usual clinical testing, while another 5 patients (17%) showed epigenetic silencing of BRCA1 in the tumor, which would have escaped standard sequencing analysis, and one had an inherited variant in another gene: RAD51C, involved in the same DNA repair mechanism as BRCA1 and BRCA2.