Other downregulated pathways included “phosphoinositide 3–kinase (PI3K) signaling in B-lymphocytes”, “ribosomal protein S6 kinase beta 1 (p70S6K) signaling”, and “triggering receptor expressed on myeloid cells 1 (TREM1) signaling systemic lupus erythematosus in B-cell-signaling pathway”. This evidence concerns the gene RPS6KB1 and systemic lupus erythematosus.