Blocking either PAR2 or specifically, the signaling functions of the TF/FVIIa binary complex suppressed tumor growth in a xenograft model in immunodeficient mice, while inhibition of the TF-initiated coagulation only exhibited a minute effect [167,244], accentuating the importance of TF-PAR2 signaling for cancer progression [245,246]. The gene discussed is TF; the disease is neoplasm.