Additionally, there has recently been emerging experimental and early clinical evidence indicating TF-dependent PAR signaling to forward tumor progression by promotion of proangiogenic processes either through upregulation of proangiogenic factors such as VEGF or downregulation of anti-angiogenic molecules like thrombospondin (Figure 3) [212,219,245,256,258,260]. The gene discussed is JTB; the disease is neoplasm.