Biopsies of newly diagnosed invasive breast cancer patients revealed a significant increase in TF and PAR2 compared to non-invasive ductal carcinoma in situ paralleled an elevated VEGF expression, emphasizing the link between tumor angiogenesis and TF-dependent PAR2 signaling in a more clinical model and further in vivo results manifest this impression [228,265]. This evidence concerns the gene VEGFA and neoplasm.