TF and breast carcinoma: Interestingly, previous studies, performed on TF-overexpressing human breast cancer cells (MCF-7), showed that the formation of the TF-FVIIa complex inhibited apoptosis in a thrombin-dependent manner by affecting the phosphorylation of both P42/44 MAPK and protein kinase B/Akt and causing stimulation in anti-apoptotic survivin expression (Figure 3) [270].