The univariate analysis of OS showed that compromised liver function (Child-Pugh B), high albumin-bilirubin grade (ALBI > 1), elevated serum alpha-fetoprotein values (AFP > 400 ng/mL), intrahepatic tumor burden > 50% (ITB > 50%), cancer-related deterioration of general conditions (ECOG-PS > 0), presence of microvascular invasion (MVI) and occurrence of dermatological adverse events during treatment (DAEs) were associated with patients’ prognosis. The gene discussed is ALB; the disease is cancer.