IDO1 and neoplasm: One study demonstrated that while IDO1 was identified as the top gene in determining low versus high tryptophan in GBM, another potential mediator of the high tryptophan metabolic phenotype in GBM, quinolinate phosphoribosyltransferase, was identified as well, suggesting alternate pathways that could be upregulated to evade IDO1 inhibition and maintain the high utilization of tryptophan in tumor cells [80].