They analysed samples from primary tumors and metastases from 98 PC patients and found that International Society of Urological Pathology (ISUP) grade was not associated with outcome or metastasis subtypes, whereas high expression on tumor epithelial cells of Ki67 in combination with low PSA expression and a low fraction of AR positive stroma cells, correlated with poor prognosis after ADT and with developing of MetB subtypes. Here, KLK3 is linked to pachyonychia congenita.