As our cohort comprised circumscribed and pediatric-type gliomas, we were able to demonstrate that p16 was focally expressed in pediatric-type, low-grade gliomas, and that overexpression of p16 was present in both IDH-wt glioblastomas and MAPK-induced, low-grade gliomas. The gene discussed is CDKN2A; the disease is central nervous system cancer.