KIT/PDGFRA-induced oncogenesis mediates the rapidly accelerated fibrosarcoma (RAF)–mitogen-activated protein kinase (MEK)–mitogen-activated protein kinases (MAPK) (RAF-MEK-MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) (PI3K-AKT) signaling pathways [10,31,32]. The gene discussed is PIK3CA; the disease is fibrosarcoma.