Peng et al. evaluated the tumor mutational burden of over seven hundred samples from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) and found 17 genes that were commonly mutated amongst both groups (APC, TP53, TNN, KRAS, MUC16, MUC4, SYNE1, FLG, FAT4, OBSCN, FAT3, RYR2, PIK3CA, FBXW7, DNAH11, MUC5B, and ZFHX4). Here, ZFHX4 is linked to neoplasm.