The most abundant protein component in the ECM is collagen, which can directly bind to the cancer cell receptors discoidin domain receptor 1 (DDR1) and discoidin domain receptor 2 (DDR2), regulate immune cell infiltration, and TGFβ expression indirectly associated with the cancer cell to induce tumor growth and metastasis [6,7]. This evidence concerns the gene TGFB1 and neoplasm.