Using linear regression analysis, we assessed the association of CD20+, CD8+, CD4+, FOXP3+ TIL-subtypes and CD4+/CD8+, FOXP3+/CD8+ ratios with the expression of HIF1α, LDH5, VD (t1, t2 and t3) and VSA (t2 and t3) in the invading tumor front. The gene discussed is CD4; the disease is neoplasm.