We first analyzed a time course of single-cell RNA-sequencing (scRNA-seq) dataset from an SCLC genetically engineered mouse model (GEMM) with an overactive Myc oncogene (Rb1fl/fl; Trp53fl/fl; Lox-Stop-Lox [LSL]-MycT58A, RPM) [10]. The gene discussed is MYC; the disease is small cell lung carcinoma.