To gain more insight into the interdependence between the HH-GLI and NOTCH pathways, we interrogated GLI1 and NOTCH1 levels in a cohort of CRC patients carrying BRAFV600E mutation (Mutation status (Core Exon)—Sieber—211—rma_sketch—huex10p; https://hgserver1.amc.nl/cgi-bin/r2/main.cgi, accessed on 15 December 2021) and found a positive and significant correlation between GLI1 and NOTCH1 (Figure 2C). Here, NOTCH1 is linked to colorectal carcinoma.