However, we observed a different behavior in the investigated models: in KRAS-mutated CRC, the inhibition of both the HH-GLI and NOTCH pathways is necessary to enhance chemosensitivity, while in BRAF-mutated CRC the inhibition of HH-GLI is sufficient to impair both signaling pathways and promote chemosensitivity. Here, GLI1 is linked to colorectal carcinoma.