Such is the case of the imprinted delta-like homolog 1 gene and the type III iodothyronine deiodinase gene (DLK1-DIO3) cluster, which includes two large miRNA clusters between other coding and non-coding transcripts, and has been reported to contribute to tumorigenesis in the lung, leukemia, breast, and hepatoblastoma, among others [14,15,16,17,18]. This evidence concerns the gene DIO3 and hepatoblastoma.