In patients with BRAF V600E+/K-mutated melanoma (n = 157), TTs prior to the diagnosis of MBM were associated with a shorter median OS as compared to no prior TTs (2.0 (IQR 0.8–7.1) vs. 10.9 (IQR 5.2–27.0) months, HR2.67, p < 0.001; Figure 4a, Table A4). Here, BRAF is linked to melanoma.