SMAD4 and neoplasm: In our univariate analyses, patients with high expression of SMAD4 in either the tumor epithelial (HR 0.5 for both nucleus and cytoplasm in univariate analyses, and 0.62 for cytoplasm in multivariate analyses) or the stromal compartment (HR 0.5 and 0.67 for cytoplasm in univariate and multivariable analyses, respectively) exhibited beneficial prognosis vs. patients with low expression.