The Cancer Genome Atlas of molecular analyses for different histologic types of endometrial cancers reveled four tumoral subtypes, each associated with a different survival profile and of great interest for prognosis, namely: POLE (Polymerase DNA Epsilon Catalytic Subunit)-mutated tumors; MMR (Mismatch Repair)-stable tumors; MMR-instable tumors; and p53-mutated tumors [4]. The gene discussed is TP53; the disease is endometrial cancer.