ERBB2 and breast cancer: On the contrary, in the study by Wu and colleagues, when applying de novo sequencing to identify circulating miRNAs associated with BC clinical outcome, lower levels of miR-375-3p significantly correlated with not achieving pCR in HER2-positive BC patients receiving doxorubicin/cyclophosphamide treatment followed by carboplatin and nab-paclitaxel plus trastuzumab [54].