UCP2 and obesity due to melanocortin 4 receptor deficiency: The polymorphism of UCP-2 gene such as −866G>A (rs659366), Ala55Val (rs660339), −5331G>A, exon 8 deletion/deletion, and 45 bp insertion/deletion in 3′UTR results in obesity, type-2 diabetes, and neural tube defects [25,26].