During cachectic conditions, the tumor and host-derived factors, such as inflammatory cytokines, catecholamine, the leukotriene inhibitory factor (LIF) [89], and parathyroid-hormone-related protein (PTHrP) [84], lead to an increase in lipolysis in adipocytes, which results in increased liberation of free fatty acids in the circulation. Here, PTHLH is linked to neoplasm.