LS-related EC is typically characterized by an endometrioid histotype, lower uterine involvement, peritumoral and tumor infiltrating lymphocytes (≥40 TIL/10HPFs), with more CD8+, CD45RO+, and PD1+ T cells at the invasive margin compared to sporadic MMRd EC, morpho-phenotypic heterogeneity, higher pathologic grade or undifferentiated forms, frequent lymphovascular invasion, deeper myometrial invasion, in particular with a typical MELF pattern [25], frequent association with synchronous ovarian cancer, early age at diagnosis (45–55 years), and lower body mass index [26]. Here, CD8A is linked to neoplasm.