MSH2 and colorectal carcinoma: However, after stratification for LS genetic variants, only MLH1 mutant carriers (MLH1mut) have a higher incidence of CRC than EC, whereas MSH6 and PMS2 mutant carriers (MSH6mut, PMS2mut) have a higher incidence of EC followed by CRC and OC, and for MSH2 mutant carriers (MSH2mut) the incidences of CRC and EC are superimposable [13].