HIF1A and neoplasm: However, a series of mechanisms, in addition to the improved TBF, significantly contribute to the increased oxygenation observed upon mHT, such as (i) increased diffusivities and (ii) intensified tumor acidosis and mHT per se, both leading to a right-shift of the HbO2 dissociation curve, thus enhancing O2 release from HbO2, and contingently (iii) HIF1-α-mediated inhibition of mitochondrial functions, a condition sometimes proposed.