Multivariate analyses incorporating clinical parameters revealed that a high level of infiltrating PD-L1+CD68+ within the CD68+ macrophage subset combined with the proportion of PD-1+CD8+ cells in the CD8+ T cell subset was an independent factor associated with a high risk of cancer-related death in PDAC patients (p = 0.037; hazard risk (HR): 2.06; 95% CI [1.04–4.0]) (Figure 6E). This evidence concerns the gene CD8A and cancer.