NOTCH1 and acute myeloid leukemia: Of the five pathogenic/likely pathogenic somatic variants that were persistent in the CR1/CR2 samples, three variants (DNMT3A p.Arg659His, RUNX1 p.Leu56Ser in Patient DX1 and NOTCH1 p.Ala1740Val in Patient DX5) were reported as having a germline predisposition in AML [37,72,73,74].