NPM1 and acute myeloid leukemia: Some of the genomic aberrations that are included in the diagnosis and prognosis of AML-NK are FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations that confer poor prognoses [6,9,10] if detected without nucleophosmin (NPM1) [6,11,12] concomitant mutations.