MEN1 and Zollinger-Ellison syndrome: The development of increasingly sensitive imaging methods for localizing these tumors (i.e., somatostatin receptor imaging, etc.)is increasing the possibility of surgical cure; therefore, improved understanding of the natural history of patients with different aspects of ZES, especially those with MEN1/ZES, and the development of novel and effective methods for the treatment of ZES patients with advanced disease can now become the main area of attention for therapeutic approaches.