In both H2R- and PPI-treated patients, symptoms (i.e., pain, diarrhea, GERD-symptoms, etc.)due to the acid hypersecretion [20,40,125] were controlled in all patients, all peptic ulcers/esophagitis or other mucosal abnormalities due to the acid hypersecretion [174] healed if initially present, and new lesions were prevented. This evidence concerns the gene HRH2 and gastroesophageal reflux disease.