Aberrant DNA hypermethylation is a prevalent epigenetic modification responsible for the inactivation of tumor suppressor genes in prostate cancer, and GSTP1, a class of Glutathione S-transferases (GSTs), a family of enzymes responsible for processes that protect cells from xenobiotics, was earliest reported to be hypermethylated in human prostate cancer [91]. The gene discussed is GSTP1; the disease is Familial prostate cancer.