Since HCC-USP15 pathways had 225 nodes, we would expect to find mean numbers of n=163×225/2423≈15.14, n=75×225/2423≈6.96 , and n=143×225/2423≈13.28  pathway hierarchies associated with cell proliferation, cell migration, and lipid processes, respectively. The gene discussed is USP15; the disease is hepatocellular carcinoma.