Motivated by the experimental evidence of a regulation by USP15 for eight exemplary members of the human USP15 PPI network, we chose all liver cancer genes with a mutation rate of over 1% (295 genes, Table S1) in the database cBioPortal for Cancer Genomics (dataset: HCC, TCGA, PanCancer Atlas) [26,27]. The gene discussed is USP15; the disease is liver cancer.