The present study identified the 10 top-ranked DEGs (AURKA, TOP2A, CDK1, PTTG1, CDKN3, CDC20, MAD2L1, CKS2, MELK, and TPX2) as the core genes (CGs), which showed Strong prognostic performance in the earlier stages of CRC. This evidence concerns the gene TOP2A and colorectal carcinoma.