Therefore, in this study, we proposed 10 top-ranked DEGs (AURKA, TOP2A, CDK1, PTTG1, CDKN3, CDC20, MAD2L1, CKS2, MELK, and TPX2) as the core genes (CGs) for early diagnosis, prognosis, and therapies of CRC. The gene discussed is AURKA; the disease is colorectal carcinoma.