Therefore, in this study, we proposed 10 top-ranked DEGs (AURKA, TOP2A, CDK1, PTTG1, CDKN3, CDC20, MAD2L1, CKS2, MELK, and TPX2) as the core genes (CGs) for early diagnosis, prognosis, and therapies of CRC. This evidence concerns the gene CKS2 and colorectal carcinoma.