The present study identified the 10 top-ranked DEGs (AURKA, TOP2A, CDK1, PTTG1, CDKN3, CDC20, MAD2L1, CKS2, MELK, and TPX2) as the core genes (CGs), which showed Strong prognostic performance in the earlier stages of CRC. The gene discussed is MAD2L1; the disease is colorectal carcinoma.