The PI3K/Akt/mTOR signaling pathway, which is a master regulator of growth and survival in normal and malignant cells, is downstream of the JAK/STAT pathway and is upregulated in many types of lymphoma, including ENKTL, where it is driven by EBV infection and LMP1 [18,23,72]. The gene discussed is PDLIM7; the disease is lymphoma.