DDX3X is an RNA helicase gene that is one of the most commonly mutated genes in ENKTL [23,28,40,64], with significant upregulation of the NF-κB and MAPK pathways found in DDX3X-mutated ENKTL tumors, suggesting that DDX3X is a possible tumor suppressor [17,19,64]. This evidence concerns the gene DDX3X and neoplasm.