Brentuximab vedotin (BV), a CD30-directed antibody-drug conjugate that is used extensively in lymphomas, has low single-agent activity in relapsed/refractory ENKTL, with a phase II study that included 7 patients with ENKTL demonstrating an ORR of 29% (1 patient with CR) [120]. This evidence concerns the gene TNFRSF8 and lymphoma.