Chemoresistance may be related to the AMP-activated protein kinase-mammalian target of the rapamycin (AMPK–mTOR) pathway, and several miRs, including miR-27a, miR-103, and miR-107, are overexpressed in patients with chemoresistant CRC (relative to patients with chemosensitive CRC) [88,89,90,91]. This evidence concerns the gene MTOR and colorectal carcinoma.