STAT3 and cancer: L1 cell adhesion molecule (L1CAM) is overexpressed in SCs adjacent to cancer cells and invaded nerves, which strongly induces cancer cells as a strong chemoattractant by activating MAP kinase signaling, and L1CAM also up-regulates the expression of metalloproteinase -2 (MMP2) and MMP9 in PDAC cells by activating STAT3 and facilitates matrix remodeling along the axon [80,81].