JUN and cancer: It has also been proposed in the literature that tumor cells activated SCs by c-Jun, while non-myelinating activated SCs form tumor-activated Schwann cell tracks (TASTs) as active scaffolds, and exert forces on cancer cells to enhance cancer mobility, promote cancer cell migration and invasion, a process similar to their reprogramming during nerve repair, leading to “neurogenesis” of precancerous cells and the periphery of tumor cells [85].