The M1 cell was activated by Th1 cytokine interferon-γ (IFN-γ), interleukin-12 (IL12), tumor necrosis factor (TNF), and microbial products to exert a tumor-killing effect, while the M2 cell was activated and differentiated by Th2 cytokines (such as IL4, IL5, IL10, IL13, colony-stimulating factor-1 (CSF1), transforming growth factor-1 (TFGβ1) and prostaglandin E2 (PGE2) to exert angiogenesis and immunosuppressive effect [41,43,45,48,49]. Here, TNF is linked to neoplasm.