By the anisotropic E-cadherin/N-cadher in junction, the frontier CAFs exert the physical force to enable the synergistic invasion of CAFs and cancer cells through a dual mechanism: CAFs pull cancer cells away from the tumor facilitating the invasion of cancer cells, while cancer cells polarize its migration away from the tumor to enhance the diffusion of CAFs [71,72]. The gene discussed is CDH1; the disease is neoplasm.