BRAF and melanoma: In fact, a markedly high prevalence of mutations at the V600 codon of BRAF (nearly all BRAF-mutated CM lesions present V600E/K variants, with particular reference to melanomas arising on skin areas intermittently exposed to UV) is lacking among MM cases; conversely, sequence variations mostly affect other regions of the BRAF gene than codon 600, though most of them in codons of the exons 11 and 15 are deputed to encode the protein domains where the kinase activity resides (among others, codons D594, G469, and K601 are frequently altered) [22,33,40,41].