BRAF and non-small cell lung carcinoma: This situation closely resembles what occurs in the adenocarcinoma subtype in the non-small cell lung cancer (NSCLC), in which the V600E mutations account for a fraction of BRAF-mutated NSCLC cases (about 40%, mainly females, and never-smoker patients), whereas the majority of them (about two thirds, regardless of the smoking habitus) carry non-V600 mutations [42].