All the 13 hub genes, i.e., ASPM, AURKA, BUB1, BUB1B, CCNA2, CCNB2, KIF2C, MELK, NCAPG, NCAPH, NUF2, PBK, and TOP2A are oncogenes and were found to be upregulated in all the samples of HCC and GBM. The gene discussed is CCNA2; the disease is hepatocellular carcinoma.