All the 13 hub genes, i.e., ASPM, AURKA, BUB1, BUB1B, CCNA2, CCNB2, KIF2C, MELK, NCAPG, NCAPH, NUF2, PBK, and TOP2A are oncogenes and were found to be upregulated in all the samples of HCC and GBM. This evidence concerns the gene BUB1B and hepatocellular carcinoma.