Moreover, authors also identified STED2/del3p.21.31, del9p21.3, and gain of chr17q21.31 are associated with relapsed/refractory (R/R) disease and TP53 disruption, whereas MED12 and DDX3X mutations are associated with unmutated IGH CLL [73]. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.