Although present in 8% of monoclonal B lymphocytosis cases, 26 CK ≥3 is associated with advanced-stage disease, cases harbouring unmutated IGHV genes (U-CLL), del(11q), TP53 aberrations [del(17p) and/or TP53 mutation], and telomere dysfunction [109,110]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.