In this study, possible associations between the adipokine chemerin and its receptor CMKLR1 with other proteins involved in steroid hormone signaling were examined in OC tissues and in silico, as the role of these proteins in cancer is yet mostly unclear.It was found that in serous ovarian cancer, both chemerin and CMKLR1 protein positively correlated with ERβ protein expression and with levels of ERRα, β, and γ; additionally, chemerin protein expression was notably associated with that of PR. This evidence concerns the gene ESR2 and cancer.