In an Italian cohort of 210 SSc patients, in which a commercially available LIA was used for the simultaneous detection of 13 SSc-associated autoantibodies, except for anti-Ro52/TRIM21 (specificity of 50%), all autoantibodies were very specific (from 93.3% anti-PM/Scl-75 to 100% anti-PDGFR, AFA, and anti-RP-11) for SSc. This evidence concerns the gene PDGFRB and systemic sclerosis.