Until now, epitranscriptomic mechanisms for silencing UMOD gene expression have not been considered but could be of great interest for ccRCC as well as other urological (e.g., urinary tract infections, urolithiasis) and nephrological (e.g., autosomal dominant tubulointerstitial kidney disease, chronic kidney disease) diseases [41,44]. This evidence concerns the gene UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia.