AFP and hepatocellular carcinoma: New classes of biomarkers with promising results in the early detection of HCC, such as microRNAs (miRNAs) [1,31,32], PIVKA II, known also as des-gamma-carboxy-prothrombin (DCP), or the fucosylated fraction of the AFP fraction (AFP-L3), stanniocalcin 2, APEX1 [33,34,35,36] have now been described.