It must be highlighted that G2019S-LRRK2 mutation has been directly linked with α-synucleinopathies [51] and that the α-Syn deposits are not confined to the organs of the central nervous system and are found in other organs and cells, including hepatocytes of different animal and cellular models of PD and in humans [7]. The gene discussed is LRRK2; the disease is Parkinson disease.