Upon hypoxia, in 22Rv1, PC-3, and LN95 prostate cancer cell lines, LIMK2 is upregulated and phosphorylates the phosphatase and TENsin homolog protein (PTEN) at five sites (Ser207, Ser226, Ser360, Ser361, and Ser362), causing its ubiquitination and degradation. Here, PTEN is linked to Familial prostate cancer.