Lagoutte et al. showed that LIMK1 regulates the cortactin association with MT1-MMP-positive endosomes and associates with the MT1-MMP in endosomes, while LIMK2 participates in the formation of invadopodia-associated cortactin pools, indicating that both are necessary for MT1-MMP-induced matrix degradation and the tumour cell invasion in breast tumour [49]. This evidence concerns the gene MMP14 and breast neoplasm.