PTEN and Familial prostate cancer: Since it has been shown in prostate cancer cell lines that LIMK2 and PTEN are engaged in a negative regulatory loop, where PTEN promotes the degradation of LIMK2 by ubiquitination and LIMK2 inhibits PTEN function and promotes its degradation, an implication of LIMK2 in PTEN-loss-driven GBM aggressiveness might be considered [109].