Several studies have shown an increase in phospho-LIMKs and phospho-cofilin in the AD brain area of patients or AD animal models by using western blot or immunofluorescence [155], more particularly in the post-synaptic compartment of excitatory synapses [161], as well as an increase in the ROCK protein level [162,163]. The gene discussed is CFL1; the disease is Alzheimer disease.